Hormonal regulation of chicken intestinal NHE and SGLT-1 activities

被引：17

作者：

De la Horra, MC ^{[1
]}

Cano, M ^{[1
]}

Peral, MJ ^{[1
]}

Calonge, ML ^{[1
]}

Ilundáin, AA ^{[1
]}

机构：

[1] Univ Sevilla, Fac Farm, Dept Fisiol & Biol Anim, E-41012 Seville, Spain

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | 2001年 / 280卷 / 03期

关键词：

low-Na+ diet; aldosterone; arginine vasotocin; brush-border membrane vesicle; sodium/hydrogen exchange;

D O I：

10.1152/ajpregu.2001.280.3.R655

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The effects of aldosterone and arginine vasotocin (AVT) on intestinal Na+/H+ exchange (NHE) and Na+-sugar cotransport (SGLT-1) activities have been investigated using brush-border membrane vesicles isolated from Hubbard chicken small and large intestines, and they were compared with those induced by either Na+ depletion or dehydration. Na+ depletion was induced by feeding the chickens with either a low- or a high-Na+ diet for either 0.5, 1, 2, 4, or 8 days. Ileal and colonic NHE2 activity increased with the duration of the Na+ depletion, whereas that of intestinal SGLT-1 decreased, reaching a plateau after 2 days of treatment. Three-hour incubation of the intestine with aldosterone produced the same effects on NHE activity as does Na+ depletion, without altering SGLT-1 activity. However, 3-h incubation of the intestine with AVT increased intestinal SGLT-1 activity, without affecting intestinal NHE activity. It is concluded that aldosterone regulates apical ileal and colonic NHE2 activity, whereas that of SGLT-1 is regulated by AVT.

引用

页码：R655 / R660

页数：6

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