Mesenchymal stem cells and neovascularization: role of platelet-derived growth factor receptors

被引：137

作者：

Ball, Stephen G. ^{[1
]}

Shuttleworth, C. Adrian ^{[1
]}

Kielty, Cay M. ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, UK Ctr Tissue Engn, Wellcome Trust Ctr Cell Matrix Res, Manchester M13 9PT, Lancs, England

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2007年 / 11卷 / 05期

基金：

英国医学研究理事会;

关键词：

mesenchymal stem cell; platelet-derived growth factor receptor; vascular endothelial growth factor; neovascularization; vasculogenesis;

D O I：

10.1111/j.1582-4934.2007.00120.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is now accumulating evidence that bone marrow-derived mesenchymal stem cells (MSCs) make an important contribution to postnatal vasculogenesis, especially during tissue ischaemia and tumour vascularization. Identifying mechanisms which regulate the role of MSCs in vasculogenesis is a key therapeutic objective, since while increased neovascularization can be advantageous during tissue ischaemia, it is deleterious during tumourigenesis. The potent angiogenic stimulant vascular endothelial growth factor (VEGF) is known to regulate MSC mobilization and recruitment to sites of neovascularization, as well as directing the differentiation of MSCs to a vascular cell fate. Despite the fact that MSCs did not express VEGF receptors, we have recently identified that VEGF-A can stimulate platelet-derived growth factor (PDGF) receptors, which regulates MSC migration and proliferation. This review focuses on the role of PDGF receptors in regulating the vascular cell fate of MSCs, with emphasis on the function of the novel VEGF-A/PDGF receptor signalling mechanism.

引用

页码：1012 / 1030

页数：19

共 123 条

[11] Platelet-derived growth factor receptor-α is a key determinant of smooth muscle α-actin filaments in bone marrow-derived mesenchymal stem cells [J].