Microwave-enhanced metal- and acid-catalysed hydrogen isotope exchange reactions

被引：24

作者：

Barthez, JM ^{[1
]}

Filikov, AV ^{[1
]}

Frederiksen, LB ^{[1
]}

Huguet, ML ^{[1
]}

Jones, JR ^{[1
]}

Lu, SY ^{[1
]}

机构：

[1] Univ Surrey, Dept Chem, Guildford GU2 5XH, Surrey, England

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1998年 / 76卷 / 06期

关键词：

microwave enhanced deuteriations; hydrogen isotope exchange;

D O I：

10.1139/cjc-76-6-726

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The benefits of using microwaves to accelerate the rates of hydrogen isotope exchange reactions are illustrated by reference to heterogeneous and homogeneous metal-catalysed reactions as well as to homogeneous acid-catalysed reactions. The results show that good incorporation of deuterium is obtained in very short time intervals, typically <20 min, and that the approach has considerable potential for the labeling of a wide range of compounds with both deuterium and, by implication, tritium.

引用

页码：726 / 728

页数：3

共 24 条

[1] TRITIATION OF ORGANIC-COMPOUNDS BY POLYMER-SUPPORTED BASE CATALYSTS
BREWER, JR
JONES, JR
LAWRIE, KWM
SAUNDERS, D
SIMMONDS, A
[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1994, 34 (08) : 787 - 794
[2] TRITIATION OF ORGANIC-COMPOUNDS BY POLYMER-SUPPORTED ACID CATALYSTS
BREWER, JR
JONES, JR
LAWRIE, KWM
SAUNDERS, D
SIMMONDS, A
[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1994, 34 (04) : 391 - 400
[3] MICROWAVE-ASSISTED ORGANIC-REACTIONS
CADDICK, S
[J]. TETRAHEDRON, 1995, 51 (38) : 10403 - 10432
[4] STEREOCHEMICAL CONSEQUENCES OF HYDROGEN-EXCHANGE AS A RESULT OF T ATOM REACTIONS ON SOLID ALIPHATIC AMINO-ACIDS
EHRENKAUFER, RLE
HEMBREE, WC
LIEBERMAN, S
WOLF, AP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (15) : 5005 - 5009
[5] T DISTRIBUTION, ENANTIOMER FORMATION, AND GLYCINE PRODUCTION IN L-VALINE LABELED BY MICROWAVE-DISCHARGE ACTIVATION OF T GAS
EHRENKAUFER, RLE
WOLF, AP
HEMBREE, WC
LIEBERMAN, S
[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1977, 13 (03) : 359 - 365
[6] GARNETT JL, 1971, CATALY REV, V5, P229
[7] Garnett JL, 1987, ISOTOPES PHYSICAL BI, V1, P86
[8] THE USE OF MICROWAVE-OVENS FOR RAPID ORGANIC-SYNTHESIS
GEDYE, R
SMITH, F
WESTAWAY, K
ALI, H
BALDISERA, L
LABERGE, L
ROUSELL, J
[J]. TETRAHEDRON LETTERS, 1986, 27 (03) : 279 - 282
[9] UNSPECIFIC TRITIUM LABELLING ACCELERATED BY MICROWAVE, ALTERNATING CURRENT AND DIRECT CURRENT ELECTRICAL DISCHARGES AND BY ULTRAVIOLET RADIATION
GHANEM, NA
WESTERMARK, T
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1960, 82 (16) : 4432 - 4433
[10] APPLICATION OF COMMERCIAL MICROWAVE-OVENS TO ORGANIC-SYNTHESIS
GIGUERE, RJ
BRAY, TL
DUNCAN, SM
MAJETICH, G
[J]. TETRAHEDRON LETTERS, 1986, 27 (41) : 4945 - 4948

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