Heparan sulphate proteoglycans:: The sweet side of development

被引：531

作者：

Häcker, U

Nybakken, K

Perrimon, N

机构：

[1] Lund Univ, Lund Ctr Stem Cell Biol & Cell Therapy, Dept Expt Med Sci, S-22184 Lund, Sweden

[2] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Genet, Boston, MA 02175 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 07期

关键词：

D O I：

10.1038/nrm1681

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.

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页码：530 / 541

页数：12

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