Ectromelia virus:: the causative agent of mousepox

被引：132

作者：

Esteban, DJ

Buller, RML

机构：

[1] St Louis Univ, Hlth Sci Ctr, Dept Mol Microbiol & Immunol, St Louis, MO 63104 USA

[2] Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 3P6, Canada

来源：

JOURNAL OF GENERAL VIROLOGY | 2005年 / 86卷

关键词：

D O I：

10.1099/vir.0.81090-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ectromelia virus (ECTV) is an orthopoxvirus whose natural host is the mouse; it is related closely to Variola virus, the causative agent of smallpox, and Monkeypox virus, the cause of an emerging zoonosis, The recent sequencing of its genome, along with an effective animal model, makes ECTV an attractive model for the study of poxvirus pathogenesis, antiviral and vaccine testing and viral immune and inflammatory responses. This review discusses the pathogenesis of mousepox, modulation of the immune response by the virus and the,cytokine and cellular components of the skin and systemic immune system that are critical to recovery from infection.

引用

收藏

页码：2645 / 2659

页数：15

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