The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains

被引：56

作者：

Oka, A

Takashima, S

机构：

[1] Tottori Univ, Fac Med, Inst Neurol Sci, Div Child Neurol, Yonago, Tottori 6838504, Japan

[2] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Retardat & Birth Defect Res, Kodaira, Tokyo 187, Japan

来源：

ACTA NEUROPATHOLOGICA | 1999年 / 97卷 / 03期

关键词：

Down's syndrome; metabotropic glutamate receptor; mGluR5; glutamate;

D O I：

10.1007/s004010050985

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the expression of metabotropic glutamate receptor 5 (mGluR5), a subtype of group I mGluRs, in the cerebral cortex of cases with Down's syndrome (DS), using immunohistochemistry and immunoblotting with this receptor. The up-regulation of mGluR5 was observed in DS by immunohistochemistry, and atrophic pyramidal neurons were immunolabelled in elderly DS cases. Western blotting confirmed the increased expression in DS brains. Since group I mGluR regulates the metabolism of amyloid precursor protein (APP) and accelerates its processing into non-amyloidogenic APP, the overexpression of mGluR5 may be related to the pathological state of APP metabolism in DS.

引用

页码：275 / 278

页数：4

共 31 条

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