Influence of vitamin C supplementation on the oxidative status of rat liver

被引：14

作者：

Djurasevic, S. F. ^{[1
]}

Djordjevic, Jelena ^{[1
]}

Drenca, Tamara ^{[1
]}

Jasnic, N. ^{[1
]}

Cvijic, Gordana ^{[1
]}

机构：

[1] Univ Belgrade, Fac Biol, Inst Physiol & Biochem, Belgrade 11000, Serbia

来源：

ARCHIVES OF BIOLOGICAL SCIENCES | 2008年 / 60卷 / 02期

关键词：

vitamin C; liver; antioxidative protection; rats;

D O I：

10.2298/ABS0802169D

中图分类号：

Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Rats have the ability to synthesize vitamin C in the liver. In the present work, we tested whether its additional intake improves antioxidative protection of the tissue. Thus, we studied the liver's oxidative status in rats given two supplements of ascorbic acid over a four-week period of time. Our results confirmed that the additional intake of ascorbate improves the livers antioxidative defense in a dose-dependent manner. The explanation for the disproportion between the ratio of employed doses of vitamin C and their effects oil the studied parameters probably lies in the mechanism of tissue accumulation of ascorbate and balance of its alimentary and endogenous availability.

引用

页码：169 / 173

页数：5

共 26 条

[1]

Measurement of plasma hydroperoxide concentration by FOX-1 assay in conjunction with triphenylphosphine [J].

Banerjee, D ;

Madhusoodanan, UK ;

Sharanabasappa, M ;

Ghosh, S ;

Jacob, J .

CLINICA CHIMICA ACTA, 2003, 337 (1-2) :147-152

[2]

Ascorbate metabolism and its regulation in animals [J].

Banhegyi, G ;

Braun, L ;

Csala, M ;

Puskas, F ;

Mandl, J .

FREE RADICAL BIOLOGY AND MEDICINE, 1997, 23 (05) :793-803

[3]

BEUTLER E, 1982, ENZYMES, P105

[4]

THE PECKING ORDER OF FREE-RADICALS AND ANTIOXIDANTS - LIPID-PEROXIDATION, ALPHA-TOCOPHEROL, AND ASCORBATE [J].

BUETTNER, GR .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 300 (02) :535-543

[5]

Does vitamin C act as a pro-oxidant under physiological conditions? [J].

Carr, A ;

Frei, B .

FASEB JOURNAL, 1999, 13 (09) :1007-1024

[6]

ASCORBATE IS AN OUTSTANDING ANTIOXIDANT IN HUMAN-BLOOD PLASMA [J].

FREI, B ;

ENGLAND, L ;

AMES, BN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) :6377-6381

[7]

A critical evaluation of the effect of sorbitol on the ferric-xylenol orange hydroperoxide assay [J].

Gay, C ;

Gebicki, JM .

ANALYTICAL BIOCHEMISTRY, 2000, 284 (02) :217-220

[8]

MICRODETERMINATION TECHNIQUES FOR H2O2 IN IRRADIATED SOLUTIONS [J].

GUPTA, BL .

MICROCHEMICAL JOURNAL, 1973, 18 (04) :363-374

[9]

Vitamin C: Antioxidant or pro-oxidant in vivo? [J].

Halliwell, B .

FREE RADICAL RESEARCH, 1996, 25 (05) :439-454

[10]

HODGES RE, 1969, AM J CLIN NUTR, V22, P535

← 1 2 3 →