Convenient one-pot synthesis of sulfonamides from thiols using trichloroisocyanuric acid

被引：29

作者：

Bonk, Jason D. ^{[1
]}

Amos, David T. ^{[1
]}

Olson, Sarah J. ^{[1
]}

机构：

[1] 3M Pharmaceut, Chem Dept, St Paul, MN 55144 USA

来源：

SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 12期

关键词：

oxidation; sulfonamides; thiol; trichloroisocyanuric acid;

D O I：

10.1080/00397910701356942

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of sulfonamides from thiols is described. In situ preparation of sulfonyl chlorides from thiols is accomplished by oxidation with trichloroisocyanuric acid (TCCA), benzyltrimethylammonium chloride and water (2.5 equiv). The sulfonyl chlorides are then further allowed to react with excess amine in the same reaction vessel. Triethylamine can be optionally added as acid scavenger.

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页码：2039 / 2050

页数：12

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