Total synthesis of gymnocin-A

被引：82

作者：

Tsukano, C ^{[1
]}

Sasaki, M ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Life Sci, Lab Biostruct Chem, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 47期

关键词：

D O I：

10.1021/ja038547b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly convergent total synthesis of gymnocin-A, a cyctotoxic polyether marine natural product, has been achieved. The synthesis features Suzuki?Miyaura coupling of the ABCD and FGHIJKLMN rings, stereoselective introduction of the C17 hydroxyl group, ring-closure of the F ring, and a late-stage incorporation of a 2-methyl-2-butenal side chain. Copyright © 2003 American Chemical Society.

引用

页码：14294 / 14295

页数：2

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