Non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma

被引：99

作者：

Cuadrado, A ^{[1
]}

Orive, A ^{[1
]}

García-Suárez, C ^{[1
]}

Domínguez, A ^{[1
]}

Fernández-Escalante, JC ^{[1
]}

Crespo, J ^{[1
]}

Pons-Romero, F ^{[1
]}

机构：

[1] Univ Hosp Marques Valdecilla, Gastroenterol & Hepatol Unit, Serv Aparato Digest, E-39008 Santander, Cantabria, Spain

来源：

OBESITY SURGERY | 2005年 / 15卷 / 03期

关键词：

obesity; liver; steatosis; hepatocellular carcinoma; insulin resistance; diabetes;

D O I：

10.1381/0960892053576596

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Non-alcoholic fatty liver disease (NAFLD) is characterized by an excessive accumulation of fatty acids and triglycerides within the cytoplasm of the hepatocytes of non-alcohol users. The natural history varies according to the initial histological diagnosis. A current consideration is that cryptogenic cirrhosis may be representative of a late stage of non-alcoholic steatohepatitis (NASH), which has lost its features of necroinflammatory activity and steatosis in up to 80% of patients. Since NASH is able to progress to cirrhosis, hepatocellular carcinoma (HCC) development may be an end-stage of this disease. We report below two clinical cases of patients diagnosed with NASH who developed HCC. The relationship between NAFLD and HCC is reviewed.

引用

页码：442 / 446

页数：5

共 42 条

[11] The role of diabetes in hepatocellular carcinoma: A case-control study among United States veterans [J].