Sex differences in prefrontal cortical brain activity during fMRI of auditory verbal working memory

被引：129

作者：

Goldstein, JM

Jerram, M

Poldrack, R

Anagnoson, R

Breiter, HC

Makris, N

Goodman, JM

Tsuang, MT

Seidman, LJ

机构：

[1] Harvard Univ,Med Sch, Brigham & Womens Hosp, Connors Ctr Womens Hlth & Gender Biol, Div Womens Hlth,Dept Psychiat, Boston, MA 02120 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Psychiat, Boston, MA USA

[3] Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, Div Publ Psychiat, Jamaica Plain, MA USA

[4] Massachusetts Gen Hosp, Athinoula Martinos Ctr Biomed Imaging, Boston, MA 02114 USA

[5] Harvard Univ,Med Sch, Brigham & Womens Hosp, Connors Ctr Womens Hlth & Gender Biol, Div Womens Hlth,Dept Med, Boston, MA 02120 USA

[6] Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, Dept Psychiat, Cambridge, MA 02138 USA

[7] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA

[8] Harvard Univ, Massachusetts Gen Hosp, Dept Radiol, Sch Med, Cambridge, MA 02138 USA

[9] Harvard Univ, Ctr Morphometr Anal, Dept Neurol, Med Sch,Dept Neurol, Boston, MA 02114 USA

[10] Harvard Univ, Ctr Morphometr Anal, Dept Neurol, Med Sch,Dept Radiol, Boston, MA 02114 USA

[11] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Cambridge, MA 02138 USA

[12] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA

来源：

NEUROPSYCHOLOGY | 2005年 / 19卷 / 04期

关键词：

sex differences; working memory; attention; fMRI;

D O I：

10.1037/0894-4105.19.4.509

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Functional imaging studies of sex effects in working memory (WMEM) are few, despite significant normal sex differences in brain regions implicated in WMEM. This functional MRI (fMRI) study tested for sex effects in an auditory verbal WMEM task in prefrontal, parietal, cingulate, and insula regions. Fourteen healthy, right-handed community subjects were comparable between the sexes, including on WMEM performance. Per statistical parametric mapping, women exhibited greater signal intensity changes in middle, inferior, and orbital prefrontal cortices than men (corrected for multiple comparisons). A test of mixed-sex groups, comparable on performance, showed no significant differences in the hypothesized regions, providing evidence for discriminant validity for significant sex differences. The findings suggest that combining men and women in fMRI studies of cognition may obscure or bias results.

引用

页码：509 / 519

页数：11

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