E-MSD: an integrated data resource for bioinformatics

被引:62
作者
Golovin, A [1 ]
Oldfield, TJ [1 ]
Tate, JG [1 ]
Velankar, S [1 ]
Barton, GJ [1 ]
Boutselakis, H [1 ]
Dimitropoulos, D [1 ]
Fillon, J [1 ]
Hussain, A [1 ]
Ionides, JMC [1 ]
John, M [1 ]
Keller, PA [1 ]
Krissinel, E [1 ]
McNeil, P [1 ]
Naim, A [1 ]
Newman, R [1 ]
Pajon, A [1 ]
Pineda, J [1 ]
Rachedi, A [1 ]
Copeland, J [1 ]
Sitnov, A [1 ]
Sobhany, S [1 ]
Suarez-Uruena, A [1 ]
Swaminathan, GJ [1 ]
Tagari, M [1 ]
Tromm, S [1 ]
Vranken, W [1 ]
Henrick, K [1 ]
机构
[1] European Bioinformat Inst, EMBL Outstn, Cambridge CB10 1SD, England
关键词
D O I
10.1093/nar/gkh078
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Macromolecular Structure Database (MSD) group (http://www.ebi.ac.uk/msd/) continues to enhance the quality and consistency of macromolecular structure data in the Protein Data Bank (PDB) and to work towards the integration of various bioinformatics data resources. We have implemented a simple form-based interface that allows users to query the MSD directly. The MSD,atlas pages' show all of the information in the MSD for a particular PDB entry. The group has designed new search interfaces aimed at specific areas of interest, such as the environment of ligands and the secondary structures of proteins. We have also implemented a novel search interface that begins to integrate separate MSD search services in a single graphical tool. We have worked closely with collaborators to build a new visualization tool that can present both structure and sequence data in a unified interface, and this data viewer is now used throughout the MSD services for the visualization and presentation of search results. Examples show-casing the functionality and power of these tools are available from tutorial webpages (http://www. ebi.ac.uk/msd-srv/docs/roadshow-tutorial/).
引用
收藏
页码:D211 / D216
页数:6
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