Tumor necrosis factor-alpha and interleukin-8 release from u937 human mononuclear cells exposed to zinc oxide in vitro - Mechanistic implications for metal fume fever

被引:17
作者
Kuschner, WG
D'Alessandro, A
Hambleton, J
Blanc, PD
机构
[1] Univ Calif San Francisco, Dept Med, Div Environm & Occupat Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Med, Div Pulm & Crit Care Med, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Med, Div Hematol & Oncol, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
关键词
D O I
10.1097/00043764-199805000-00008
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Respiratory exposure to zinc oxide results ist metal fume fever, a flu-like illness characterized by dose-dependent increases in pulmonary tumor necrosis factor-alpha (TNF) and interleukin-8 (IL-8). To examine whether mononuclear cells are a source of these proinflammatory cytokines, we exposed U937 cells to zinc oxide in vitro, Cell culture supernatant TNF and IL-8 was measured after 3, 8, and 24 hours of exposure to zinc oxide in varying concentrations, Zinc oxide exposure in vitro led to TNF release in a dose-dependent manner at 3, 8 and 24 hours (analysis of variance [ANOVA] P = 0.0001). IL-8 demonstrated a statistically significant zinc exposure response cat 8 hours (ANOVA P = 0.005) and 24 hours (ANOVA P = 0.02). IL-8 at 8 hours correlated with 3-hour TNF levels (r = 0.52, P = 0.04). These data demonstrate that in vitro zinc oxide exposure stimulates U937 mononuclear cells to release TNF and IL-8 consistent with in vivo observations in metal fume fever.
引用
收藏
页码:454 / 459
页数:6
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