HIV postexposure prophylaxis in the 21st century

被引:13
作者
Henderson, DK [1 ]
机构
[1] NIH, Warren G Magnuson Clin Ctr, Bethesda, MD 20892 USA
关键词
D O I
10.3201/eid0702.010221
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The administration of postexposure prophylaxis has become the standard of care for occupational exposures to HIV. We have learned a great deal about the safety and potential efficacy of these agents, as well as the optimal management of health-care workers occupationally exposed to HIV. This article describes the current state of knowledge in this field, identifies substantive questions to be answered, and summarizes basic principles of postexposure management.
引用
收藏
页码:254 / 258
页数:5
相关论文
共 44 条
[11]   HIV-SPECIFIC T-HELPER ACTIVITY IN SERONEGATIVE HEALTH-CARE WORKERS EXPOSED TO CONTAMINATED BLOOD [J].
CLERICI, M ;
LEVIN, JM ;
KESSLER, HA ;
HARRIS, A ;
BERZOFSKY, JA ;
LANDAY, AL ;
SHEARER, GM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (01) :42-46
[12]   REDUCTION OF MATERNAL-INFANT TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 WITH ZIDOVUDINE TREATMENT [J].
CONNOR, EM ;
SPERLING, RS ;
GELBER, R ;
KISELEV, P ;
SCOTT, G ;
OSULLIVAN, MJ ;
VANDYKE, R ;
BEY, M ;
SHEARER, W ;
JACOBSON, RL ;
JIMENEZ, E ;
ONEILL, E ;
BAZIN, B ;
DELFRAISSY, JF ;
CULNANE, M ;
COOMBS, R ;
ELKINS, M ;
MOYE, J ;
STRATTON, P ;
BALSLEY, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (18) :1173-1180
[13]   Effect of zidovudine postexposure prophylaxis on the development of HIV-specific cytotoxic T-lymphocyte responses in HIV-exposed healthcare workers [J].
D'Amico, R ;
Pinto, LA ;
Meyer, P ;
Landay, AL ;
Harris, AA ;
Clerici, M ;
Berzofsky, JA ;
Shearer, GM ;
Kessler, HA .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 1999, 20 (06) :428-430
[14]   6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Cote d'Ivoire and Burkina Faso:: a double-blind placebo-controlled multicentre trial [J].
Dabis, F ;
Msellati, P ;
Meda, N ;
Welffens-Ekra, C ;
You, B ;
Manigart, O ;
Leroy, V ;
Simonon, A ;
Cartoux, M ;
Combe, P ;
Ouangré, A ;
Ramon, R ;
Ky-Zerbo, O ;
Montcho, C ;
Salamon, R ;
Rouzioux, C ;
Van de Perre, P ;
Mandelbrot, L .
LANCET, 1999, 353 (9155) :786-792
[15]   Mechanisms of virologic failure in previously untreated HIV-infected patients from a trial of induction-maintenance therapy [J].
Descamps, D ;
Flandre, P ;
Calvez, V ;
Peytavin, G ;
Meiffredy, V ;
Collin, G ;
Delaugerre, C ;
Robert-Delmas, S ;
Bazin, B ;
Aboulker, JP ;
Pialoux, G ;
Raffi, F ;
Brun-Vézinet, F .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (02) :205-211
[16]  
Devereux HL, 1999, AIDS, V13, pF123, DOI 10.1097/00002030-199912240-00001
[17]   Maternal viral genotypic zidovudine resistance and infrequent failure of zidovudine therapy to prevent perinatal transmission of human immunodeficiency virus type 1 in Pediatric AIDS Clinical Trials Group protocol 076 [J].
Eastman, PS ;
Shapiro, DE ;
Coombs, RW ;
Frenkel, LM ;
McSherry, GD ;
Britto, P ;
Herman, SA ;
Sperling, RS .
JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (03) :557-564
[18]   Analysis of the maternal components of the AIDS Clinical Trial Group 076 zidovudine regimen in the prevention of mother-to-infant transmission of human immunodeficiency virus type 1 [J].
Frenkel, LM ;
Cowles, MK ;
Shapiro, DE ;
Melvin, AJ ;
Watts, DH ;
McLellan, C ;
Mohan, K ;
Murante, B ;
Burchett, S ;
Bryson, YJ ;
OSullivan, MJ ;
Mitchell, C ;
Landers, D .
JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (04) :971-974
[19]   Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVMET 012 randomised trial [J].
Guay, LA ;
Musoke, P ;
Fleming, T ;
Bagenda, D ;
Allen, M ;
Nakabiito, C ;
Sherman, J ;
Bakaki, P ;
Ducar, C ;
Deseyve, M ;
Emel, L ;
Mirochnick, M ;
Fowler, MG ;
Mofenson, L ;
Miotti, P ;
Dransfield, K ;
Bray, D ;
Mmiro, F ;
Jackson, JB .
LANCET, 1999, 354 (9181) :795-802
[20]  
HAIDUVEN DJ, 1995, INFECT CONT HOSP EP, V16, P582