Human granulocytic anaplasmosis and macrophage activation

被引：58

作者：

Dumler, J. Stephen

Barat, Nicole C.

Barat, Christopher E.

Bakken, Johan S.

机构：

[1] Johns Hopkins Univ, Sch Med, Div Med Microbiol, Dept Pathol, Baltimore, MD 21205 USA

[2] Villa Julie Coll, Stevenson, MD USA

[3] St Lukes Infect Dis Associates, Duluth, MN USA

来源：

CLINICAL INFECTIOUS DISEASES | 2007年 / 45卷 / 02期

关键词：

D O I：

10.1086/518834

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with human granulocytic anaplasmosis present with fever, thrombocytopenia, leukopenia, and an elevated aspartate transaminase level. Clinical and histopathologic features of severe disease suggest macrophage activation. Twenty-nine patients with human granulocytic anaplasmosis had higher ferritin, interleukin-10, interleukin-12 p70, and interferon-gamma levels than did control subjects matched for age and sex; severity correlated with triglyceride, ferritin, and interleukin-12 p70 levels. Several severely affected patients had cases that fulfilled macrophage activation syndrome diagnostic criteria. Macrophage activation and excessive cytokine production may belie tissue injury associated with Ananplasma phagocytophilum infection.

引用

收藏

页码：199 / 204

页数：6

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