Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression

被引：14

作者：

Landberg, G

Nilsson, K

Jirström, K

Rydén, L

Kitching, R

Burger, AM

Seth, A ^{[1
]}

机构：

[1] Univ Toronto, Sunnybrook & Womens Coll, Hlth Sci Ctr, Dept Lab Med & Pathobiol,Lab Mol Pathol, Toronto, ON, Canada

[2] Lund Univ, UMAS, Dept Lab Med, Div Pathol, Malmo, Sweden

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2005年 / 89卷 / 03期

关键词：

breast cancer; cyclin I; proliferation; VEGF;

D O I：

10.1007/s10549-004-2230-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the present study, cyclin I protein expression in 114 invasive human breast cancers was correlated with cell cycle and angiogenesis-related proteins and clinico-pathological data. A strong association was found between cytoplasmic cyclin I staining and VEGF (p = 0.001) as well as the VEGF receptor KDR (p = 0.001), suggesting a link between cyclin I and angiogenesis.

引用

页码：313 / 316

页数：4

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