Polyacrylamide-based glycoconjugates as tools in glycobiology

被引：170

作者：

Bovin, NV ^{[1
]}

机构：

[1] Russian Acad Sci, MM Shemyakin Bioorgan Chem Inst, Moscow 117871, Russia

来源：

GLYCOCONJUGATE JOURNAL | 1998年 / 15卷 / 05期

关键词：

antibodies; assays; carbohydrates; cytochemistry; diagnostics; glycoconjugates; glycosyltransferases; histochemistry; immunoassay; lectins; polyacrylamide;

D O I：

10.1023/A:1006963717646

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review describes the synthesis, physicochemical characteristics and application for studying carbohydrate-binding proteins of polyacrylamide (PAA) type neoglycoconjugates. An approach to the synthesis of conjugates based on the interaction of activated polyacrylic acid with omega-aminoalkyl glycosides has been developed. Both the molecules of Glyc-PAA and the conjugates bearing various labels and effecters, as well as sorbents, and glycosurfaces can be designed using this method. Examples of the application of the conjugates as tools for the study of lectins, antibodies, and glycosyltransferases in glycobiology, cytochemistry and histochemistry are described along with the prospects of the further development of the presented approach in glycotechnology and medicine.

引用

页码：431 / 446

页数：16

共 99 条

[31] TUMOR LECTINOLOGY - AT THE INTERSECTION OF CARBOHYDRATE-CHEMISTRY, BIOCHEMISTRY, CELL BIOLOGY, AND ONCOLOGY
GABIUS, HJ
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1988, 27 (10) : 1267 - 1276
[32] GABIUS HJ, 1988, LECTINS GLYCOCONJUGA
[33] CARRIER-IMMOBILIZED DERIVATIZED LYSOGANGLIOSIDE GM1 IS A LIGAND FOR SPECIFIC BINDING-SITES IN VARIOUS HUMAN TUMOR-CELL TYPES AND PERIPHERAL-BLOOD LYMPHOCYTES AND MONOCYTES
GABIUS, S
KAYSER, K
HELLMANN, KP
CIESIOLKA, T
TRITTIN, A
GABIUS, HJ
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 169 (01) : 239 - 244
[34] Gabius S, 1996, EUR J PHARM BIOPHARM, V42, P250
[35] Galanina OE, 1997, J MOL RECOGNIT, V10, P139, DOI 10.1002/(SICI)1099-1352(199705/06)10:3<139::AID-JMR358>3.0.CO
[36] 2-R
[37] GALANINA OE, 1991, RUSS J BIOORG CHEM+, V17, P664
[38] GALANINA OE, 1992, RUSS J BIOORG CHEM+, V18, P171
[39] GALANINA OE, 1991, RUSS J BIOORG CHEM+, V17, P181
[40] Specification of receptor-binding phenotypes of influenza virus isolates from different hosts using synthetic sialylglycopolymers: Non-egg-adapted human H1 and H3 influenza A and influenza B viruses share a common high binding affinity for 6'-sialyl(N-acetyllactosamine)
Gambaryan, AS
Tuzikov, AB
Piskarev, VE
Yamnikova, SS
Lvov, DK
Robertson, JS
Bovin, NV
Matrosovich, MN
[J]. VIROLOGY, 1997, 232 (02) : 345 - 350

← 1 2 3 4 5 6 7 8 9 10 →