Synthesis and antimicrobial activity of coumarin 7-substituted cephalosporins and sulfones

被引：39

作者：

Bonsignore, L

Cottiglia, F

Elkhaili, H

Jehl, F

Lavagna, SM

Loy, G

Manna, F

Monteil, H

Pompei, D

Secci, D

机构：

[1] Univ Cagliari, Dipartimento Farm Chim Tecnol, I-09124 Cagliari, Italy

[2] Univ Rome La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy

[3] Fac Med Strasbourg, Inst Bacteriol, F-67000 Strasbourg, France

来源：

FARMACO | 1998年 / 53卷 / 06期

关键词：

carbon suboxide; cephalosporins; sulfones; antimicrobial activity;

D O I：

10.1016/S0014-827X(98)00047-0

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Some coumarin 7-substituted cephalosporins and related sulfones were prepared and an antimicrobial assay was performed. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) carried out on cephalosporins showed a potential activity of some of the synthesized compounds against Gram-positive microorganisms. The tests performed on the corresponding sulfones showed no significant activity, neither as antimicrobial agents nor as inhibitors of beta-lactamase. An association of sulfone 6a with ampicillin was observed to inhibit Gram-positive microorganisms with a lower MIC than for ampicillin alone. (C) 1998 Elsevier Science S.A. All rights reserved.

引用

页码：425 / 430

页数：6

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