The synthesis of a novel non-C2 symmetric H4-BINOL ligand and its application to titanium-catalyzed enantioselective addition of diethylzinc to aldehydes

被引：64

作者：

Shen, XQ ^{[1
]}

Guo, H ^{[1
]}

Ding, KL ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Organomet Chem Lab, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 21期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0957-4166(00)00413-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of the novel non-C-2 symmetric ligand (R)-5,6,7,8-tetrahydro-1,1'-binaphthol has been achieved via partial reduction of 2,2'-bis(methoxymethoxy)-1,1'-binaphthyl with Raney Ni-Al alloy in dilute aqueous NaOH solution followed by hydrolysis with HCl. Its titanium complex was found to be an effective catalyst in the asymmetric addition of diethylzinc to a variety of aldehydes, leading to the formation of secondary alcohols in high yields with good to excellent enantioselectivities. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4321 / 4327

页数：7

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