The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease

被引：154

作者：

Lee, Hyun Ju ^{[2
,3
]}

Lee, Jong Kil ^{[1
,2
]}

Lee, Hyun ^{[2
,3
]}

Shin, Ji-woong ^{[2
,3
]}

Carter, Janet E. ^{[4
]}

Sakamoto, Toshiro ^{[5
]}

Jin, Hee Kyung ^{[1
,2
]}

Bae, Jae-sung ^{[2
,3
]}

机构：

[1] Kyungpook Natl Univ, Coll Vet Med, Cell & Matrix Res Inst, Dept Lab Anim Med, Taegu 702701, South Korea

[2] Kyungpook Natl Univ, Stem Cell Neuroplast Res Grp, Taegu 702701, South Korea

[3] Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Physiol,BSEI,World Class Univ Program, Taegu 702701, South Korea

[4] UCL, Dept Mental Hlth Sci, Royal Free & Univ Coll Med Sch, London, England

[5] Okinawa Inst Sci & Technol, Unit Mol Neurobiol Learning & Memory, Okinawa, Japan

来源：

NEUROSCIENCE LETTERS | 2010年 / 481卷 / 01期

关键词：

Human umbilical cord blood-derived mesenchymal stem cells; Acutely induced Alzheimer's disease model; Spatial learning and memory; Apoptosis; Intracerebral transplantation; OXIDATIVE STRESS; NEURODEGENERATIVE DISEASES; APOPTOSIS; DEFICITS; RAT; INFLAMMATION; ACTIVATION; HEATSTROKE; PROTECT; MODEL;

D O I：

10.1016/j.neulet.2010.06.045

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The neuropathological hallmarks of Alzheimer's disease (AD) include the presence of extracellular amyloid-beta peptide (A beta) in the form of amyloid plaques in the brain parenchyma and neuronal loss The mechanism associated with neuronal death by amyloid plaques is unclear but oxidative stress and ghat activation has been implicated Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) are being scrutinized as a potential therapeutic tool to prevent various neurodegenerative diseases including AD. However, the therapeutic impact of hUCB-MSCs in AD has not yet been reported. Here we undertook in vitro work to examine the potential impact of hUCB-MSCs treatment on neuronal loss using a paradigm of cultured hippocampal neurons treated with A beta. We confirmed that hUCB-MSCs co-culture reduced the hippocampal apoptosis induced by A beta treatment. Moreover, in an acute AD mouse model to directly test the efficacy of hUCB-MSCs treatment on AD-related cognitive and neuropathological outcomes, we demonstrated that markers of glial activation, oxidative stress and apoptosis levels were decreased in AD mouse brain. Interestingly. hUCB-MSCs treated AD mice demonstrated cognitive rescue with restoration of learning/memory function. These data suggest that hUCB-MSCs warrant further investigation as a potential therapeutic agent in AD. (C) 2010 Elsevier Ireland Ltd. All rights reserved

引用

页码：30 / 35

页数：6

共 23 条

[1]

Stem cell factor and mesenchymal and neural stem cell transplantation in a rat model of Huntington's disease [J].