Membrane dynamics and the biogenesis of lysosomes (Review)

被引:122
作者
Luzio, JP
Poupon, V
Lindsay, MR
Mullock, BM
Piper, RC
Pryor, PR
机构
[1] Univ Cambridge, Addenbrookes Hosp, Cambridge Inst Med Res, Cambridge CB2 2XY, England
[2] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2XY, England
[3] Univ Iowa, Dept Physiol & Biophys, Iowa City, IA 52242 USA
关键词
endocytosis; multivesicular body; endosome-lysosome fusion; membrane traffic; organelle biogenesis;
D O I
10.1080/0968768031000089546
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lysosomes are dynamic organelles receiving membrane traffic input from the biosynthetic, endocytic and autophagic pathways. They may be regarded as storage organelles for acid hydrolases and are capable of fusing with late endosomes to form hybrid organelles where digestion of endocytosed macromolecules occurs. Reformation of lysosomes from the hybrid organelles involves content condensation and probably removal of some membrane proteins by vesicular traffic. Lysosomes can also fuse with the plasma membrane in response to cell surface damage and a rise in cytosolic Ca2+ concentration. This process is important in plasma membrane repair. The molecular basis of membrane traffic pathways involving lysosomes is increasingly understood, in large part because of the identification of many proteins required for protein traffic to vacuoles in the yeast Saccharomyces cerevisiae. Mammalian orthologues of these proteins have been identified and studied in the processes of vesicular delivery of newly synthesized lysosomal proteins from the trans-Golgi network, fusion of lysosomes with late endosomes and sorting of membrane proteins into lumenal vesicles. Several multiprotein oligomeric complexes required for these processes have been identified. The present review focuses on current understanding of the molecular mechanisms of fusion of lysosomes with both endosomes and the plasma membrane and on the sorting events required for delivery of newly synthesized membrane proteins, endocytosed membrane proteins and other endocytosed macromolecules to lysosomes.
引用
收藏
页码:141 / 154
页数:14
相关论文
共 172 条
[91]   Synaptotagmin VII regulates Ca2+-dependent exocytosis of lysosomes in fibroblasts [J].
Martinez, I ;
Chakrabarti, S ;
Hellevik, T ;
Morehead, J ;
Fowler, K ;
Andrews, NW .
JOURNAL OF CELL BIOLOGY, 2000, 148 (06) :1141-1149
[92]   Clostridial neurotoxin-insensitive vesicular SNAREs in exocytosis and endocytosis [J].
Martinez-Arca, S ;
Alberts, P ;
Galli, T .
BIOLOGY OF THE CELL, 2000, 92 (06) :449-453
[93]   TRANSLOCATION AND CLUSTERING OF ENDOSOMES AND LYSOSOMES DEPENDS ON MICROTUBULES [J].
MATTEONI, R ;
KREIS, TE .
JOURNAL OF CELL BIOLOGY, 1987, 105 (03) :1253-1265
[94]  
McNeil PL, 2002, J CELL SCI, V115, P873
[95]   Coping with the inevitable: how cells repair a torn surface membrane [J].
McNeil, PL ;
Terasaki, M .
NATURE CELL BIOLOGY, 2001, 3 (05) :E124-E129
[96]   Endocytosis and molecular sorting [J].
Mellman, I .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 :575-625
[97]   The road taken: Past and future foundations of membrane traffic [J].
Mellman, I ;
Warren, G .
CELL, 2000, 100 (01) :99-112
[98]  
Meyer C, 2001, J CELL SCI, V114, P4469
[99]   μ1A-adaptin-deficient mice:: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors [J].
Meyer, C ;
Zizioli, D ;
Lausmann, S ;
Eskelinen, EL ;
Hamann, J ;
Saftig, P ;
von Figura, K ;
Schu, P .
EMBO JOURNAL, 2000, 19 (10) :2193-2203
[100]   Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells [J].
Mizushima, N ;
Yamamoto, A ;
Hatano, M ;
Kobayashi, Y ;
Kabeya, Y ;
Suzuki, K ;
Tokuhisa, T ;
Ohsumi, Y ;
Yoshimori, T .
JOURNAL OF CELL BIOLOGY, 2001, 152 (04) :657-667