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Correlation of telomere lengths in normal and cancers tissue in the large bowel

被引：61
作者：
Nakamura, K
Furugori, E
Esaki, Y
Arai, T
Sawabe, M
Okayasu, I
Fujiwara, M
Kammori, M
Mafune, K
Kato, M
Oshimura, M
Sasajima, K
Takubo, K
机构：
[1] Tokyo Metropolitan Inst Gerontol, Dept Clin Pathol, Itabashi Ku, Tokyo 1730015, Japan
[2] Tokyo Metropolitan Geriatr Hosp, Dept Pathol, Itabashi Ku, Tokyo 1730015, Japan
[3] Kitasato Univ, Fac Med, Dept Pathol, Sagamihara, Kanagawa 2280829, Japan
[4] Tokyo Red Cross, Med Ctr, Dept Pathol, Shibuya Ku, Tokyo 1500012, Japan
[5] Univ Tokyo, Fac Med, Dept Surg 3, Bunkyo Ku, Tokyo 1128688, Japan
[6] Univ Tokyo, Fac Med, Dept Surg 2, Bunkyo Ku, Tokyo 1130033, Japan
[7] Tottori Univ, Sch Life Sci, Dept Mol & Cell Genet, Yonago, Tottori 6838503, Japan
[8] Nippon Med Sch, Dept Surg 1, Bunkyo Ku, Tokyo 1130022, Japan
来源：
CANCER LETTERS | 2000年 / 158卷 / 02期
关键词：
telomere shortening; large intestine; aging; colon carcinoma;
D O I：
10.1016/S0304-3835(00)00521-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The hypothesis that telomeres in colorectal cancer cells exhibit age-related shortening, as in normal cells of the colorectal epithelium, was tested with samples of non-cancerous mucosa and cancer tissue from 124 patients (aged 29-97 years). Shortening with aging could be demonstrated for both normal and cancer tissues; regression analysis showed rates for length reduction of 44 and 50 base pair/year. respectively. Straight, essentially parallel. lines were obtained for the two cases. normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码：179 / 184
页数：6
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