Shedding the hydrophilic mantle of polymersomes

被引：24

作者：

Brinkhuis, Rene P. ^{[1
]}

Visser, Taco R. ^{[1
]}

Rutjes, Floris P. J. T. ^{[1
]}

van Hest, Jan C. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands

来源：

POLYMER CHEMISTRY | 2011年 / 2卷 / 03期

关键词：

INTRACELLULAR DRUG-DELIVERY; DIBLOCK COPOLYMERS; CONTROLLED-RELEASE; BLOCK-COPOLYMERS; FUNCTIONALIZED POLYMERS; MODULAR SYNTHESIS; VESICLES; MICELLES; PEG; HYDROLYSIS;

D O I：

10.1039/c0py00316f

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

Block copolymers of polybutadiene-b-poly(ethylene glycol) were prepared in which both segments were coupled via an acid sensitive hydrazone moiety. Polymersomes that were subsequently formed showed a strong pH-dependent colloidal stability as a result of the pH sensitive removal of the PEG block. By mixing this stimulus responsive block polymer with an inert analogue it was possible to systematically remove percentages of PEG from the polymersome mantle. The minimum amount of surface PEGylation needed to retain stable polymersomes was found to be as low as five percent.

引用

页码：550 / 552

页数：3

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