Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: Design of potent antagonists containing the 3-azaspiro[5.5]undec-9-yl template

被引：10

作者：

Pandey, A

Seroogy, J

Volkots, D

Smyth, MS

Rose, J

Mehrotra, MM

Heath, J

Ruhter, G

Schotten, T

Scarborough, RM ^{[1
]}

机构：

[1] COR Therapeut Inc, Dept Med & Biol Chem, San Francisco, CA 94080 USA

[2] Lilly Res Labs, Hamburg, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(01)00216-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological activity of novel glycoprotein IIb-IIIa anatagonists containing 3-azaspiro[5.5]undec-9-yl nucleus are described. The potent activity elf these compounds as platelet aggregation inhibitors demonstrates the utility of the monoazaspirocyclic structure as central template for nonpeptide RGD mimics. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1293 / 1296

页数：4

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