The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

被引:72
作者
Abel, M [1 ]
Hoenderop, J [1 ]
Bindels, R [1 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
关键词
ECaC; kidney; intestine; active Ca2+ transport; vitamin D; estrogen; parathyroid hormone; channel (in)activation;
D O I
10.1007/s00210-005-1021-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The epithelial Ca2+ channels TRPV5 and TRPV6 represent a new family of Ca2+ channels that belongs to the superfamily of transient receptor potential channels. TRPV5 and TRPV6 constitute the apical Ca2+ entry mechanism in active Ca2+ transport in kidney and intestine. The central role of TRPV5 and TRPV6 in active Ca2+ (re)absorption makes it a prime target for regulation to maintain Ca2+ balance. This review covers the hormonal regulation, interaction with accessory proteins and (patho)physiological implications of these epithelial Ca2+ channels.
引用
收藏
页码:295 / 306
页数:12
相关论文
共 132 条
  • [1] Decrease in kidney calbindin-D 28kDa as a possible mechanism mediating cyclosporine A- and FK-506-induced calciuria and tubular mineralization
    Aicher, L
    Meier, G
    Norcross, AJ
    Jakubowski, J
    Varela, MD
    Cordier, A
    Steiner, S
    [J]. BIOCHEMICAL PHARMACOLOGY, 1997, 53 (05) : 723 - 731
  • [2] ASPLIN JR, 1996, KIDNEY, P1893
  • [3] Stone prevention: why so little progress?
    Baumann, JM
    [J]. UROLOGICAL RESEARCH, 1998, 26 (02): : 77 - 81
  • [4] Physiological roles of axonal ankyrins in survival of premyelinated axons and localization of voltage-gated sodium channels
    Bennett, V
    Lambert, S
    [J]. JOURNAL OF NEUROCYTOLOGY, 1999, 28 (4-5): : 303 - 318
  • [5] BINDELS RJM, 1993, J EXP BIOL, V184, P89
  • [6] Ca2+ dependence of the Ca2+selective TRPV6 channel
    Bödding, M
    Flockerzi, V
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (35) : 36546 - 36552
  • [7] Ca2+-calmodulin regulates receptor-operated Ca2+ entry activity of TRPC6 in HEK-293 cells
    Boulay, G
    [J]. CELL CALCIUM, 2002, 32 (04) : 201 - 207
  • [8] Effects of excess PTH on nonclassical target organs
    Bro, S
    Olgaard, K
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 1997, 30 (05) : 606 - 620
  • [9] AN ANALYSIS OF INTESTINAL CALCIUM-TRANSPORT ACROSS THE RAT INTESTINE
    BRONNER, F
    PANSU, D
    STEIN, WD
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 250 (05): : G561 - G569
  • [10] Mechanisms of intestinal calcium absorption
    Bronner, F
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2003, 88 (02) : 387 - 393