The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

被引：72

作者：

Abel, M ^{[1
]}

Hoenderop, J ^{[1
]}

Bindels, R ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2005年 / 371卷 / 04期

关键词：

ECaC; kidney; intestine; active Ca2+ transport; vitamin D; estrogen; parathyroid hormone; channel (in)activation;

D O I：

10.1007/s00210-005-1021-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The epithelial Ca2+ channels TRPV5 and TRPV6 represent a new family of Ca2+ channels that belongs to the superfamily of transient receptor potential channels. TRPV5 and TRPV6 constitute the apical Ca2+ entry mechanism in active Ca2+ transport in kidney and intestine. The central role of TRPV5 and TRPV6 in active Ca2+ (re)absorption makes it a prime target for regulation to maintain Ca2+ balance. This review covers the hormonal regulation, interaction with accessory proteins and (patho)physiological implications of these epithelial Ca2+ channels.

引用

页码：295 / 306

页数：12

共 132 条

[71] Gene structure and chromosomal mapping of human epithelial calcium channel
Müller, D
Hoenderop, JGJ
Merkx, GFM
van Os, CH
Bindels, RJM
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 275 (01) : 47 - 52
[72] Epithelial Ca2+ channel (ECAC1) in autosomal dominant idiopathic hypercalciuria
Müller, D
Hoenderop, JGJ
Vennekens, R
Eggert, P
Harangi, F
Méhes, K
Garcia-Nieto, V
Claverie-Martin, F
van Os, CH
Nilius, B
Bindels, RJM
[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2002, 17 (09) : 1614 - 1620
[73] Nemeth Edward F., 1996, P1019
[74] Calcimimetics with potent and selective activity on the parathyroid calcium receptor
Nemeth, EF
Steffey, ME
Hammerland, LG
Hung, BCP
Van Wagenen, BC
DelMar, EG
Balandrin, MF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) : 4040 - 4045
[75] The role of calcium in apoptosis
Nicotera, P
Orrenius, S
[J]. CELL CALCIUM, 1998, 23 (2-3) : 173 - 180
[76] Competitive regulation of CaT-like-mediated Ca2+ entry by protein kinase C and calmodulin
Niemeyer, BA
Bergs, C
Wissenbach, U
Flockerzi, V
Trost, C
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (06) : 3600 - 3605
[77] Downregulation of Ca2+ and Mg2+ transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesemia
Nijenhuis, T
Hoenderop, JGJ
Bindels, RJM
[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (03): : 549 - 557
[78] Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney
Nijenhuis, T
Hoenderop, JGJ
Loffing, J
van der Kemp, AWCM
van Os, CH
Bindels, RJM
[J]. KIDNEY INTERNATIONAL, 2003, 64 (02) : 555 - 564
[79] Ketolides: the future of the macrolides?
Nilius, AM
Ma, ZK
[J]. CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (05) : 493 - 500
[80] The carboxyl terminus of the epithelial Ca2+ channel ECaC1 is involved in Ca2+-dependent inactivation
Nilius, B
Weidema, F
Prenen, J
Hoenderop, JGJ
Vennekens, R
Hoefs, S
Droogmans, G
Bindels, RJM
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2003, 445 (05): : 584 - 588

← 3 4 5 6 7 8 9 10 11 12 →