Acquisition and persistence of human papillomavirus infection in younger men: A prospective follow-up study among Danish soldiers

被引:120
作者
Kjaer, SK
Munk, C
Winther, JF
Jorgensen, HO
Meijer, CJLM
van den Brule, AJC
机构
[1] Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen, Denmark
[2] Def Med Training Ctr, Gentofte, Denmark
[3] Free Univ Amsterdam Hosp, Dept Pathol, Amsterdam, Netherlands
[4] PAMM Inst, Lab Pathol & Med Microbiol, Eindhoven, Netherlands
关键词
D O I
10.1158/1055-9965.EPI-04-0754
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
No data is yet available on incidence or persistence of human papillomavirus (HPV) infection in men. We enrolled 374 younger male conscripts (18-29 years) in a prospective study, and they were examined twice with an interval of 6 to 8 months. Data collection included a questionnaire and a sample of cells from the penis for HPV detection using PCR. In addition, the presence of Chlamydia trachomatis DNA was assessed in urine samples by means of PCR. The HPV prevalence at the first and second examinations was 33.8% and 31.9%, respectively. The acquisition rate of HPV (overall) during follow-up was 13.8%, and nearly one fourth of the participants were HPV positive at both examinations. Number of sex partners during follow-up was the most important risk factor for acquiring HPV (odds ratio, 17.2; 95% confidence interval, 4.6-64.7, for >= 3 partners versus <= 1 partner). In contrast, acquisition of a new HPV type in initially HPV-positive men was strongly related to having multiple HPV types at enrollment (OR, 4.1; 95% confidence interval, 1.4-12.3). This was also the most important risk factor for HPV persistence together with current smoking and having a high-risk HPV type at enrollment. This is the first study to assess risk factors for acquisition and persistence of HPV. The sexually transmitted nature of the infection is confirmed, and the data point to an important role of having multiple HPV types for persistence.
引用
收藏
页码:1528 / 1533
页数:6
相关论文
共 24 条
  • [11] PERSISTENCE OF TYPE-SPECIFIC HUMAN PAPILLOMAVIRUS INFECTION AMONG CYTOLOGICALLY NORMAL WOMEN
    HILDESHEIM, A
    SCHIFFMAN, MH
    GRAVITT, PE
    GLASS, AG
    GREER, CE
    ZHANG, T
    SCOTT, DR
    RUSH, BB
    LAWLER, P
    SHERMAN, ME
    KURMAN, RJ
    MANES, MM
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (02) : 235 - 240
  • [12] PREVALENCE AND RISK-FACTORS OF GENITAL HUMAN PAPILLOMAVIRUS (HPV) INFECTIONS IN HEALTHY-MALES - A STUDY ON FINNISH CONSCRIPTS
    HIPPELAINEN, M
    SYRJANEN, S
    HIPPELAINEN, M
    KOSKELA, H
    PULKKINEN, J
    SAARIKOSKI, S
    SYRJANEN, K
    [J]. SEXUALLY TRANSMITTED DISEASES, 1993, 20 (06) : 321 - 328
  • [13] Natural history of cervicovaginal papillomavirus infection in young women
    Ho, GYF
    Bierman, R
    Beardsley, L
    Chang, CJ
    Burk, RD
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (07) : 423 - 428
  • [14] A general primer GP5+/GP6+-mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papillomavirus genotypes in cervical scrapings
    Jacobs, MV
    Snijders, PJF
    vandenBrule, AJC
    Helmerhorst, TJM
    Meijer, CJLM
    Walboomers, JMM
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (03) : 791 - 795
  • [15] Kjaer SK, 2001, CANCER EPIDEM BIOMAR, V10, P101
  • [16] Kjaer SK, 1997, CANCER EPIDEM BIOMAR, V6, P799
  • [17] High prevalence of human papillomavirus infection in Mexican males -: Comparative study of penile-urethral swabs and urine samples
    Lazcano-Ponce, E
    Herrero, R
    Muñoz, N
    Hernandez-Avila, M
    Salmerón, J
    Leyva, A
    Meijer, CJLM
    Walboomers, JMM
    [J]. SEXUALLY TRANSMITTED DISEASES, 2001, 28 (05) : 277 - 280
  • [18] A prospective study of human papillomavirus (HPV) type 16 DNA detection by polymerase chain reaction and its association with acquisition and persistence of other HPV types
    Liaw, KL
    Hildesheim, A
    Burk, RD
    Gravitt, P
    Wacholder, S
    Manos, MM
    Scott, DR
    Sherman, ME
    Kurman, RJ
    Glass, AG
    Anderson, SM
    Schiffman, M
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (01) : 8 - 15
  • [19] Joint effects of different human papillomaviruses and Chlamydia trachomatis infections on risk of squamous cell carcinoma of the cervix uteri
    Luostarinen, T
    Lehtinen, M
    Bjorge, T
    Abeler, V
    Hakama, M
    Hallmans, G
    Jellum, E
    Koskela, P
    Lenner, P
    Lie, AK
    Paavonen, J
    Pukkala, E
    Saikku, P
    Sigstad, E
    Thoresen, S
    Youngman, LD
    Dillner, J
    Hakulinen, T
    [J]. EUROPEAN JOURNAL OF CANCER, 2004, 40 (07) : 1058 - 1065
  • [20] Epidemiologic classification of human papillomavirus types associated with cervical cancer
    Muñoz, N
    Bosch, FX
    de Sanjosé, S
    Herrero, R
    Castellsagué, X
    Shah, KV
    Snijders, PJF
    Meijer, CJLM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (06) : 518 - 527