Transcranial magnetic stimulation of left prefrontal cortex impairs working memory

被引：103

作者：

Mull, BR ^{[1
]}

Seyal, M ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Neurol, Clin Neurophysiol Sect, Sacramento, CA 95817 USA

来源：

CLINICAL NEUROPHYSIOLOGY | 2001年 / 112卷 / 09期

关键词：

working memory; dorsolateral prefrontal cortex; functional disruption; transcranial magnetic stimulation;

D O I：

10.1016/S1388-2457(01)00606-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: Several lines of evidence suggest that the prefrontal cortex is involved in working whether transient functional disruption of the dorsolateral prefrontal cortex (DLPFC) would impair performance in a sequential-letter working memory task. Methods: Subjects were shown sequences of letters and asked to state whether the letter just displayed was the same as the one presented 3-back. Single-pulse transcranial magnetic stimulation (TMS) was applied over the DLPFC between letter presentations. Results: TMS applied over the left DLPFC resulted in increased errors relative to no TMS controls. TMS over the right DLPFC did not alter working memory performance. Conclusion: Our results indicate that the left prefrontal cortex has a crucial role in at least one type of working memory. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1672 / 1675

页数：4

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