F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease

被引：153

作者：

Nourooz-Zadeh, J

Liu, EHC

Yhlen, B

Änggård, EE

Halliwell, B

机构：

[1] Univ London Univ Coll, Dept Med, Ctr Clin Pharmacol & Therapeut Toxicol, London WC1E 6JJ, England

[2] Univ London Kings Coll, Pharmacol Grp, Neurodegenerat Dis Res Ctr, London WC2R 2LS, England

[3] St Bartholomews Hosp, William Harvey Res Inst, London, England

[4] Astra Hassle AB, Molndal, Sweden

来源：

JOURNAL OF NEUROCHEMISTRY | 1999年 / 72卷 / 02期

关键词：

docosahexaenoic acid; Alzheimer's disease; isoprostanes; lipid peroxidation; arachidonic acid;

D O I：

10.1046/j.1471-4159.1999.0720734.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

F-2-isoprostanes are prostaglandin-like compounds derived from free radical-catalysed peroxidation of arachidonic acid. Peroxidation of eicosapentaenoic acid produces F-3-isoprostanes, whereas peroxidation of docosahexaenoic acid would give F-4-isoprostanes. This study demonstrates the presence of esterified F-4-isoprostanes in human brain and shows that levels are elevated in certain brain cortex regions in Alzheimer's disease. Our data with Alzheimer's disease suggest that analysis of F-4-isoprostanes will provide new opportunities to study lipid peroxidation in the neurodegenerative diseases.

引用

页码：734 / 740

页数：7

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[11] ABNORMAL PROFILES OF POLYUNSATURATED FATTY-ACIDS IN THE BRAIN, LIVER, KIDNEY AND RETINA OF PATIENTS WITH PEROXISOMAL DISORDERS [J].