Early-life infection leads to altered BDNF and IL-1β mRNA expression in rat hippocampus following learning in adulthood

被引：80

作者：

Bilbo, Staci D. ^{[1
]}

Barrientos, Ruth M. ^{[2
]}

Eads, Andrea S. ^{[2
]}

Northcutt, Alexis ^{[2
]}

Watkins, Linda R. ^{[2
]}

Rudy, Jerry W. ^{[2
]}

Maier, Steven F. ^{[2
]}

机构：

[1] Duke Univ, Dept Psychiat & Neurosci, Durham, NC 27708 USA

[2] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2008年 / 22卷 / 04期

关键词：

cytokines; interleukin-1; postnatal; immune; cognition; fear conditioning;

D O I：

10.1016/j.bbi.2007.10.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neonatal bacteria] infection in rats leads to profound hippocampal-dependent memory impairments following a peripheral immune challenge in adulthood. Here, we determined whether neonatal infection plus an immune challenge in adult rats is associated with impaired induction of brain-derived neurotrophic factor (BDNF) within the hippocampus (CA1, CA3, and dentate gyrus) following fear conditioning. BDNF is well characterized for its critical role in learning and memory. Rats injected on postnatal day 4 with PBS (vehicle) or Escherichia coli received as adults either no conditioning or a single 2 min trial of fear conditioning. Half of the rats in the conditioned group then received a peripheral injection of 25 mu g/kg lipopolysaccharide (LPS) and all were sacrificed 1 or 4 h later. Basal (unconditioned) BDNF mRNA did not differ between groups. However, following conditioning, neonatal infection with E coli led to decreased BDNF mRNA induction in all regions compared to PBS-treated rats. This decrease in E coli-treated rats was accompanied by a large increase in IL-1 beta mRNA in CA1. Taken together, these data indicate that early infection strongly influences the induction of IL-1 beta and BDNF within distinct regions of the hippocampus, which likely contribute to observed memory impairments in adulthood. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：451 / 455

页数：5

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