Autoimmune disease: why and where it occurs

被引：422

作者：

Marrack, P ^{[1
]}

Kappler, J

Kotzin, BL

机构：

[1] Howard Hughes Med Inst, Denver, CO USA

[2] Natl Jewish Med & Res Ctr, Integrated Dept Immunol, Denver, CO USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Biochem & Mol Biol, Denver, CO USA

[4] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA

[5] Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 08期

关键词：

D O I：

10.1038/90935

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autoimmune disease is controlled by genetic and environmental factors. Both of these affect susceptibility to autoimmunity at three levels: the overall reactivity of the immune system, the specific antigen and its presentation, and the target issue.

引用

页码：899 / 905

页数：7

共 100 条

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