Autoimmune disease: why and where it occurs

被引：422

作者：

Marrack, P ^{[1
]}

Kappler, J

Kotzin, BL

机构：

[1] Howard Hughes Med Inst, Denver, CO USA

[2] Natl Jewish Med & Res Ctr, Integrated Dept Immunol, Denver, CO USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Biochem & Mol Biol, Denver, CO USA

[4] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA

[5] Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 08期

关键词：

D O I：

10.1038/90935

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autoimmune disease is controlled by genetic and environmental factors. Both of these affect susceptibility to autoimmunity at three levels: the overall reactivity of the immune system, the specific antigen and its presentation, and the target issue.

引用

页码：899 / 905

页数：7

共 100 条

[91] Genetic analysis of autoimmune disease
Vyse, TJ
Todd, JA
[J]. CELL, 1996, 85 (03) : 311 - 318
[92] Genetic susceptibility to systemic lupus erythematosus
Vyse, TJ
Kotzin, BL
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 : 261 - 292
[93] Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice
Vyse, TJ
Drake, CG
Rozzo, SJ
Roper, E
Izui, S
Kotzin, BL
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (08) : 1762 - 1772
[94] Genetic dissection of systemic lupus erythematosus
Wakeland, EK
Wandstrat, AE
Liu, K
Morel, L
[J]. CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (06) : 701 - 707
[95] CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells
Wong, FS
Visintin, I
Wen, L
Flavell, RA
Janeway, CA
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (01) : 67 - 76
[96] A novel polymorphism of Fc gamma RIIIa (CD16) alters receptor function and predisposes to autoimmune disease
Wu, JM
Edberg, JC
Redecha, PB
Bansal, V
Guyre, PM
Coleman, K
Salmon, JE
Kimberly, RP
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (05) : 1059 - 1070
[97] MOLECULAR MIMICRY IN T-CELL-MEDIATED AUTOIMMUNITY - VIRAL PEPTIDES ACTIVATE HUMAN T-CELL CLONES SPECIFIC FOR MYELIN BASIC-PROTEIN
WUCHERPFENNIG, KW
STROMINGER, JL
[J]. CELL, 1995, 80 (05) : 695 - 705
[98] YEAMAN SJ, 1988, LANCET, V1, P1067
[99] Antiislet autoantibodies usually develop sequentially rather than simultaneously
Yu, LP
Rewers, M
Gianani, R
Kawasaki, E
Zhang, YJ
Verge, C
Chase, P
Klingensmith, G
Erlich, H
Norris, J
Eisenbarth, GS
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (12) : 4264 - 4267
[100] Yunis E J, 1975, Birth Defects Orig Artic Ser, V11, P185

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