Tools for human leukocyte antigen antibody detection and their application to transplanting sensitized patients

被引:85
作者
Fuggle, Susan V. [1 ,2 ,3 ]
Martin, Susan [4 ]
机构
[1] Churchill Hosp, Oxford Transplant Ctr, Oxford OX3 7LJ, England
[2] Univ Oxford, Nuffield Dept Surg, Oxford, England
[3] UK Transplant, Bristol, Avon, England
[4] Manchester Royal Infirm, Transplantat Lab, Manchester M13 9WL, Lancs, England
关键词
renal transplantation; HLA antibody detection; sensitized patients;
D O I
10.1097/TP.0b013e31817c90f5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In recent years there have been major advances in the technology for the detection and definition of human leukocyte antigen antibodies. In this overview we describe the evolution in laboratory technology, the techniques currently available and consider their application in antibody specificity definition and in understanding a patient's sensitization profile. We discuss the importance of antibody specificity definition in facilitating efficient national organ allocation and informing clinical discussion regarding the appropriate pathway for sensitized patients awaiting renal transplantation.
引用
收藏
页码:384 / 390
页数:7
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