A convenient synthesis of (E)-α-alkylidene-γ-lactams and (E)-3-alkylideneoxindoles by rhodium-catalyzed intramolecular hydroamidation

被引：39

作者：

Kobayashi, Y

Kamisaki, H

Yanada, K

Yanada, R

Takemoto, Y ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[2] Setsunan Univ, Fac Pharmaceut Sci, Hirakata, Osaka 5730101, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 44期

关键词：

rhodium catalyst; carbonylative cyclization; C-H activation; formarnides; hydroamidation;

D O I：

10.1016/j.tetlet.2005.08.133

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodium-catalyzed carbonylative cyclization without carbon monoxide was investigated. Cyclization of various form-amides having alkynyl groups proceeded smoothly in the presence of Rh-4(CO)(12) to provide alpha-alkylidene-gamma-lactams or 3-alkylideneoxindoles in moderate to good yields with high (E)-selectivity. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：7549 / 7552

页数：4

共 38 条

[1] Ru3(CO)12-catalyzed cyclocarbonylation of yne-aldehydes to bicyclic α,β-unsaturated γ-butyrolactones [J].