Therapeutic siRNAs

被引：98

作者：

Sioud, M ^{[1
]}

机构：

[1] Norwegian Radium Hosp, Dept Immunol, Mol Med Grp, N-310 Oslo, Norway

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2004年 / 25卷 / 01期

关键词：

D O I：

10.1016/j.tips.2003.11.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The ability of small-interfering RNAs (siRNAs) to silence gene expression in somatic mammalian cells has provided researchers with a novel tool to block the expression of disease-causing genes, provided that their mRNA sequences are known. siRNAs can be delivered to cells either exogenously as synthetic agents or endogenously as gene-encoding siRNAs. Recent studies demonstrate the general application of siRNAs to silence gene expression in a range of cell types and in whole mammals. Beyond their value for dissecting gene functions and target validation, siRNAs also hold great potential as gene-specific therapeutic agents.

引用

页码：22 / 28

页数：7

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