Allostery: DNA does it, too

被引：28

作者：

Chaires, Jonathan B. ^{[1
]}

机构：

[1] Univ Louisville, James Graham Brown Canc Ctr, Louisville, KY 40202 USA

来源：

ACS CHEMICAL BIOLOGY | 2008年 / 3卷 / 04期

关键词：

D O I：

10.1021/cb800070s

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Allostery is a central concept for understanding protein function and regulation. It is less well appreciated that DNA is allosteric, too, and that DNA conformational changes can by coupled to protein binding interactions on the DNA lattice. Allosteric DNA interactions are emerging as important features in the assembly of the molecular machines that regulate transcription.

引用

页码：207 / 209

页数：3

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