Asymmetric synthesis of α,α-disubstituted α-amino acid derivatives using MABR promoted rearrangement

被引：26

作者：

Matsushita, M ^{[1
]}

Maeda, H ^{[1
]}

Kodama, M ^{[1
]}

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(98)00576-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient route for the asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acids derivatives (1, 2, and 3) starting from readily available epoxy silyl ethers (6) has been developed. High enantiomeric purity can be realized by the present method using a combination of MABR rearrangement of a chiral epoxide and Curtius rearrangement. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3749 / 3752

页数：4

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