Asymmetric synthesis of α,α-disubstituted α-amino acid derivatives using MABR promoted rearrangement

被引:26
作者
Matsushita, M [1 ]
Maeda, H [1 ]
Kodama, M [1 ]
机构
[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan
关键词
D O I
10.1016/S0040-4039(98)00576-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient route for the asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acids derivatives (1, 2, and 3) starting from readily available epoxy silyl ethers (6) has been developed. High enantiomeric purity can be realized by the present method using a combination of MABR rearrangement of a chiral epoxide and Curtius rearrangement. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3749 / 3752
页数:4
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