Ipso- or cine-substitutions of 6-haloimidazo[1,2-a]pyridine derivatives with different azoles depending on the reaction conditions

被引：34

作者：

Enguehard, C

Allouchi, H

Gueiffier, A

Buchwald, SL

机构：

[1] UFR Sci Pharmaceut, EA 3247, Chim Therapeut Lab, F-37200 Tours, France

[2] UFR Sci Pharmaceut, Chim Phys Lab, F-37200 Tours, France

[3] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 14期

关键词：

D O I：

10.1021/jo034439w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

reactivity of 6-haloimidazo[1,2-alpha]pyridine toward different azoles is reported. The process was shown to be highly dependent on the reaction conditions. Using copper(l) catalyst, the product of ;ipso substitution was obtained. In the absence of copper, with cesium carbonate in N,N-dimethylformamide, a cine substitution took place.

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页码：5614 / 5617

页数：4

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