Catalytic amination of 5-iodouracil derivatives

被引：53

作者：

Arterburn, JB ^{[1
]}

Pannala, M ^{[1
]}

Gonzalez, AM ^{[1
]}

机构：

[1] New Mexico State Univ, Dept Chem & Biochem, Las Cruces, NM 88003 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 08期

基金：

美国国家卫生研究院;

关键词：

uracil; heterocycle; catalytic amination; copper catalyst; nickel catalyst;

D O I：

10.1016/S0040-4039(00)02315-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Heterocyclic 5-amino uracil derivatives were prepared by catalytic amination of 1,3-dibenzyl-5-iodouracil using (CuOTf)(2). PhH, 1,10-phenanthroline, dibenzylidene acetone, and Cs2CO3 as base in xylenes at 95 degreesC. Imidazole and 2-amino thiazoline were problematic using the Cu catalyst, but were effectively coupled using Ni(COD)(2), dppf, and (NaOBu)-O-t in toluene at 100 degreesC. These are the first examples of catalytic amination with a uracil substrate. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1475 / 1477

页数：3

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