Fibre-fluorescence in situ hybridization unravels apparently seven DAZ genes or pseudogenes clustered within a Y-chromosome region frequently deleted in azoospermic males

被引：40

作者：

Gläser, B

Yen, PH

Schempp, W

机构：

[1] Univ Freiburg, Inst Human Genet & Anthropol, D-79106 Freiburg, Germany

[2] Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Div Med Genet, Torrance, CA 90502 USA

来源：

CHROMOSOME RESEARCH | 1998年 / 6卷 / 06期

关键词：

azoospermia factor; DAZ gene family; fibre-FISH; human Y chromosome; physical mapping;

D O I：

10.1023/A:1009256613348

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using the technique of 'fibre-FISH' (fluorescence in situ hybridization), we describe the direct visualization of seven longer DAZ signal stretches and in addition a maximum of four isolated single DAZ signals on Y-chromatin fibres of four different individuals. These seven longer DAZ signal stretches may represent seven DAZ genes or pseudogenes, whereas the single DAZ signals may represent truncated DAZ genes.

引用

页码：481 / 486

页数：6

共 20 条

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