Synergistic antibacterial effects of β-lactam antibiotic combined with silver nanoparticles

被引:395
作者
Li, P
Li, J
Wu, CZ
Wu, QS [1 ]
Li, J
机构
[1] Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China
[2] Anhui Agr Univ, Dept Food Sci & Technol, Hefei 200036, Peoples R China
关键词
D O I
10.1088/0957-4484/16/9/082
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The bactericidal action of silver (0) nanoparticles and amoxicillin on Escherichia coli is studied, respectively. Increasing concentration of both arnoxicillin (0-0.525 mg ml(-1)) and silver nanoparticles (0-40 mu g ml(-1)) showed a higher antibacterial effect in Luria-Bertani (LB) medium. Escherichia coli cells have different bactericidal sensitivity to them. When amoxicillin and silver nanoparticles are combined, it results in greater bactericidal efficiency on Escherichia coli cells than when they were applied separately. Dynamic tests on bacterial growth indicated that exponential and stationary phases are greatly decreased and delayed in the synergistic effect of amoxicillin and silver nanoparticles. In addition, the effect induced by a preincubation with silver nanoparticles is examined. The results show that solutions with more silver nanoparticles have better antimicrobial effects. One hypothesized mechanism is proposed to explain this phenomenon.
引用
收藏
页码:1912 / 1917
页数:6
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