Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis

被引:209
作者
Jiang, Chunyang [1 ]
Li, Xin [2 ,3 ]
Zhao, Hui [1 ]
Liu, Huibin [4 ]
机构
[1] Tianjin Union Med Ctr, Dept Thorac Surg, 190 Jieyuan Rd, Tianjin 300121, Peoples R China
[2] Tianjin Med Univ Gen Hosp, Tianjin Key Lab Lung Canc Metastasis & Tumor Micr, Tianjin Lung Canc Inst, 154 An Shan Rd, Tianjin 300052, Peoples R China
[3] Tianjin Med Univ Gen Hosp, Dept Lung Canc Surg, 154 An Shan Rd, Tianjin 300052, Peoples R China
[4] Xinjiang Med Univ, Dept Pharmacol, Affiliated Tumor Hosp, Urumqi 830011, Peoples R China
关键词
Long non-coding RNA; Cancer; Invasion; Metastasis; Biomarker; SQUAMOUS-CELL CARCINOMA; NEGATIVE PROGNOSTIC-FACTOR; TO-MESENCHYMAL-TRANSITION; BLADDER-CANCER METASTASIS; POOR-PROGNOSIS; HEPATOCELLULAR-CARCINOMA; UP-REGULATION; REGULATES PROLIFERATION; COLORECTAL-CANCER; GASTRIC-CANCER;
D O I
10.1186/s12943-016-0545-z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Long non-coding RNAs (lncRNAs) play important roles in malignant neoplasia. Indeed, many hallmarks of cancer define that the malignant phenotype of tumor cells are controlled by lncRNAs. Despite a growing number of studies highlighting their importance in cancer, there has been no systematic review of metastasis-associated lncRNAs in various cancer types. Accordingly, we focus on the key metastasis-related lncRNAs and outline their expression status in cancer tissues by reviewing the previous stuides, in order to summarize the nowadays research achivements for lncRNAs related to cancer metastasis. Medline, EMBASE, as well as PubMed databases were applied to study lncRNAs which were tightly associated with tumor invasion and metastasis. Up to now, a substantial number of lncRNAs have been found to have important biological functions. In this review, according to their various features in cancer, lncRNAs were roughly divided into three categories: promoting tumor invasion and metastasis, negative regulation of tumor metastasis and with dual regulatory roles. The present studies may establish the foundation for both further research on the mechanisms of cancer progression and future lncRNA-based clinical applications.
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页数:15
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