Solid support synthesis of 2-substituted dibenz[b,f]oxazepin-11(10H)-ones via SNAr methodology on AMEBA resin.

被引：46

作者：

Ouyang, X ^{[1
]}

Tamayo, N ^{[1
]}

Kiselyov, AS ^{[1
]}

机构：

[1] Amgen Inc, Small Mol Drug Discovery, Thousand Oaks, CA 91320 USA

来源：

TETRAHEDRON | 1999年 / 55卷 / 10期

关键词：

oxazepines; supported reagents/reactions; solid-phase synthesis;

D O I：

10.1016/S0040-4020(99)00061-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient assembly of dibenz[b,f]oxazepin-11(10H)-ones utilizing the SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support is reported. The flexibility of this synthesis, as well as the excellent purity (>90%) of the final products are the distinctive characteristics of the resulting library. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2827 / 2834

页数：8

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