Stroke risk modifies regional white matter differences in mild cognitive impairment

被引:21
作者
Delano-Wood, Lisa [2 ]
Bondi, Mark W. [1 ,2 ]
Jak, Amy J. [2 ]
Horne, Nikki R. [2 ]
Schweinsburg, Brian C. [2 ]
Frank, Lawrence R. [4 ]
Wierenga, Christina E. [2 ]
Delis, Dean C. [2 ]
Theilmann, Rebecca J. [4 ]
Salmon, David P. [3 ]
机构
[1] VA San Diego Healthcare Syst, Psychol Serv 116B, La Jolla, CA 92161 USA
[2] Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Sch Med, Dept Radiol, La Jolla, CA 92093 USA
基金
美国国家卫生研究院;
关键词
MCI; Mild cognitive impairment; Stroke risk; Framingham; Aging; White matter; Diffusion tensor imaging (DTI); HUMAN CORPUS-CALLOSUM; AGE-RELATED-CHANGES; ALZHEIMERS-DISEASE; VASCULAR RISK; DEMENTIA; BRAIN; MRI; HIPPOCAMPAL; ANISOTROPY; DIFFUSIVITY;
D O I
10.1016/j.neurobiolaging.2008.09.013
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Forty non-demented older adults who were divided into two groups on the basis of their cognitive status (MCI: n=20; normal control: n=20) underwent diffusion tensor imaging, and estimates of fractional anisotropy (FA) and mean diffusivity (MD) were obtained for the genu and splenium of the corpus callosum. Results demonstrated the following: (1) group comparisons revealed that splenium FA was significantly lower in MCI participants than in NC participants, despite no differences in gross morphometry or hippocampal volumes; (2) in the overall sample, higher stroke risk was associated with lower white matter integrity, particularly in the genu; (3) increased stroke risk was more strongly associated with poorer splenium FA in those with MCI than in normal elderly; (4) splenium FA significantly predicted performance on verbal memory (adjusting for the effects of age, education, and whole brain volume). Findings demonstrate a relationship between increased vascular burden and white matter changes, and they support the possibility that posterior white matter pathology may contribute to the development of MCI-related cognitive changes. Published by Elsevier Inc.
引用
收藏
页码:1721 / 1731
页数:11
相关论文
共 86 条
  • [21] Delis DC, 1987, The California verbal learning test
  • [22] MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD
    deToledo-Morrell, L
    Stoub, TR
    Bulgakova, M
    Wilson, RS
    Bennett, DA
    Leurgans, S
    Wuu, J
    Turner, DA
    [J]. NEUROBIOLOGY OF AGING, 2004, 25 (09) : 1197 - 1203
  • [23] MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease
    Dickerson, BC
    Goncharova, I
    Sullivan, MP
    Forchetti, C
    Wilson, RS
    Bennett, DA
    Beckett, LA
    deToledo-Morrell, L
    [J]. NEUROBIOLOGY OF AGING, 2001, 22 (05) : 747 - 754
  • [24] Mini-mental State Examination performance in mild cognitive impairment subtypes
    Diniz, Breno S. O.
    Yassuda, Monica S.
    Nunes, Paula V.
    Radanovic, Marcia
    Forlenza, Orestes V.
    [J]. INTERNATIONAL PSYCHOGERIATRICS, 2007, 19 (04) : 647 - 656
  • [25] Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    Du, YS
    Ma, ZZ
    Lin, SZ
    Dodel, RC
    Gao, F
    Bales, KR
    Triarhou, LC
    Chernet, E
    Perry, KW
    Nelson, DLG
    Luecke, S
    Phebus, LA
    Bymaster, FP
    Paul, SM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) : 14669 - 14674
  • [26] Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease
    Esiri, MM
    Nagy, Z
    Smith, MZ
    Barnetson, L
    Smith, AD
    [J]. LANCET, 1999, 354 (9182) : 919 - 920
  • [27] Predicting conversion to dementia in mild cognitive impairment by volumetric and diffusivity measurements of the hippocampus
    Fellgiebel, A
    Dellani, PR
    Greverus, D
    Scheurich, A
    Stoeter, P
    Müller, MJ
    [J]. PSYCHIATRY RESEARCH-NEUROIMAGING, 2006, 146 (03) : 283 - 287
  • [28] Ultrastructural hippocampal and white matter alterations in mild cognitive impairment:: A diffusion tensor imaging study
    Fellgiebel, A
    Wille, P
    Müller, MJ
    Winterer, G
    Scheurich, A
    Vucurevic, G
    Schmidt, LG
    Stoeter, P
    [J]. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2004, 18 (01) : 101 - 108
  • [29] Quantitative evaluation of automated skull-stripping methods applied to contemporary and legacy images: Effects of diagnosis, bias correction, and slice location
    Fennema-Notestine, C
    Ozyurt, IB
    Clark, CP
    Morris, S
    Bischoff-Grethe, A
    Bondi, MW
    Jernigan, TL
    Fischl, B
    Segonne, F
    Shattuck, DW
    Leahy, RM
    Rex, DE
    Toga, AW
    Zou, KH
    Birn, M
    Brown, GG
    [J]. HUMAN BRAIN MAPPING, 2006, 27 (02) : 99 - 113
  • [30] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN
    FOLSTEIN, MF
    FOLSTEIN, SE
    MCHUGH, PR
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) : 189 - 198