Use of glyceryl trinitrate ointment in the treatment of anal fissure

被引:87
作者
Lund, JN
Armitage, NC
Scholefield, JH
机构
[1] Department of Surgery, Queen's Medical Centre, University Hospital
关键词
D O I
10.1002/bjs.1800830615
中图分类号
R61 [外科手术学];
学科分类号
摘要
Anal fissure is often treated surgically by sphincterotomy. There is growing concern over the effects of this procedure on continence, Nitric oxide donors such as glyceryl trinitrate are thought to cause a reversible 'chemical sphincterotomy', capable of healing the fissure. Twenty-one consecutive patients with chronic anal fissure (13 women,mean age 36 years) were treated for 4-6 weeks with 0.2 per cent glyceryl trinitrate ointment applied to the fissure twice daily. Maximum anal resting pressure (MARP) was measured before and after application of the ointment at the first visit, There were 16 posterior and five anterior fissures. Mean(s.d.) MARP felt from 118.7(45.0) to 70.3(34.1)cmH(2)O over 20 min after application of the ointment (P < 0.001). Healing was complete in 11 patients at 4 weeks and in 18 at 6 weeks. The fissure recurred in four patients after cessation of treatment; three were successfully treated by further glyceryl trinitrate. Mild headache occurred in four patients. Anal fissure can be successfully treated with 0.2 per cent glyceryl trinitrate ointment applied topically.
引用
收藏
页码:776 / 777
页数:2
相关论文
共 13 条
[11]   SPHINCTER INJURY AFTER ANAL DILATATION DEMONSTRATED BY ANAL ENDOSONOGRAPHY [J].
SPEAKMAN, CTM ;
BURNETT, SJD ;
KAMM, MA ;
BARTRAM, CI .
BRITISH JOURNAL OF SURGERY, 1991, 78 (12) :1429-1430
[12]   PROSPECTIVE-STUDY OF THE EXTENT OF INTERNAL ANAL-SPHINCTER DIVISION DURING LATERAL SPHINCTEROTOMY [J].
SULTAN, AH ;
KAMM, MA ;
NICHOLLS, RJ ;
BARTRAM, CI .
DISEASES OF THE COLON & RECTUM, 1994, 37 (10) :1031-1033
[13]  
WATSON SJ, 1995, DIS COLON RECTUM, V38, pP29