The synthesis of phosphaisocoumarins by Cu(I)-catalyzed intramolecular cyclization of o-ethynylphenylphosphonic acid monoesters

被引:95
作者
Peng, AY [1 ]
Ding, YX [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
关键词
D O I
10.1021/ja038627f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Cu(I)-catalyzed intramolecular cyclization of o-ethynylphenylphosphonic acid monoethyl esters was examined, and a new class of six-membered phosphorus heterocycles was formed with high regioselectivity and good yields. The present reaction is the first example of intramolecular addition of P?OH to alkynes, which provides a convenient way to synthesize novel phosphorus heterocycles having potential bioactivities. Copyright © 2003 American Chemical Society.
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页码:15006 / 15007
页数:2
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