The synthesis of phosphaisocoumarins by Cu(I)-catalyzed intramolecular cyclization of o-ethynylphenylphosphonic acid monoesters

被引：95

作者：

Peng, AY ^{[1
]}

Ding, YX ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 49期

关键词：

D O I：

10.1021/ja038627f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cu(I)-catalyzed intramolecular cyclization of o-ethynylphenylphosphonic acid monoethyl esters was examined, and a new class of six-membered phosphorus heterocycles was formed with high regioselectivity and good yields. The present reaction is the first example of intramolecular addition of P?OH to alkynes, which provides a convenient way to synthesize novel phosphorus heterocycles having potential bioactivities. Copyright © 2003 American Chemical Society.

引用

页码：15006 / 15007

页数：2

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