Switch-peptides:: Controlling self-assembly of amyloid β-derived peptides in vitro by consecutive triggering of acyl migrations

被引：84

作者：

Dos Santos, S ^{[1
]}

Chandravarkar, A ^{[1
]}

Mandal, B ^{[1
]}

Mimna, R ^{[1
]}

Murat, K ^{[1
]}

Saucède, L ^{[1
]}

Tella, P ^{[1
]}

Tuchscherer, G ^{[1
]}

Mutter, M ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 34期

关键词：

D O I：

10.1021/ja052083v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The sequential triggering (Soff → Son) of O, N-acyl migrations (AcM) by chemical and enzymatic methods (Ti) in peptides containing structure-disrupting switch-elements, S (switch-peptides), offers a novel tool for studying in statu nascendi the onset and inhibition of polypeptide folding and self-assembly as a key process in degenerative diseases. Copyright © 2005 American Chemical Society.

引用

页码：11888 / 11889

页数：2

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