Synthesis and antimicrobial studies of chalconyl pregnenolones

被引：47

作者：

Banday, Abid H. ^{[1
]}

Zargar, M. Iqbal ^{[2
]}

Ganaie, Bashir A. ^{[3
]}

机构：

[1] Islamia Coll Sci & Commerce, Dept Chem, Srinagar 190009, J&K, India

[2] Univ Kashmir, Dept Pharmaceut Sci, Srinagar 190009, J&K, India

[3] Univ Kashmir, Dept Biochem, Srinagar 190009, J&K, India

来源：

STEROIDS | 2011年 / 76卷 / 12期

关键词：

Chalcone; Pregnenolone; TLC; Antimicrobials; Microbial strains; ANTICANCER; DERIVATIVES;

D O I：

10.1016/j.steroids.2011.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

An efficient and facile synthesis of 17-chalconyl derivatives of pregnenolone and their evaluation as antimicrobial agents against various microbial strains is reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to the corresponding chalcone derivatives. The compounds 3a-3j showed significant antimicrobial activity against all microbial strains used for testing. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1358 / 1362

页数：5

共 28 条

[1]

Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects [J].

Akihisa, T ;

Tokuda, H ;

Hasegawa, D ;

Ukiya, M ;

Kimura, Y ;

Enjo, F ;

Suzuki, T ;

Nishino, H .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (01) :38-42

[2]

ANTICANCER AND ANTIOXIDANT ACTIVITY OF SYNTHETIC CHALCONES AND RELATED-COMPOUNDS [J].

ANTO, RJ ;

SUKUMARAN, K ;

KUTTAN, G ;

RAO, MNA ;

SUBBARAJU, V ;

KUTTAN, R .

CANCER LETTERS, 1995, 97 (01) :33-37

[3]

Synthesis of novel steroidal D-ring substituted isoxazoline derivatives of 17-oxoandrostanes [J].

Banday, Abid H. ;

Singh, Swarn ;

Alam, M. Sarwar ;

Reddy, Dorna M. ;

Gupta, B. D. ;

Kumar, H. M. Sampath .

STEROIDS, 2008, 73 (03) :370-374

[4]

Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents [J].

Banday, Abid H. ;

Mir, Bilal P. ;

Lone, Imtiyaz H. ;

Suri, K. A. ;

Kumar, H. M. Sampath .

STEROIDS, 2010, 75 (12) :805-809

[5]

D-ring substituted 1,2,3-triazolyl 20-keto pregnenanes as potential anticancer agents: Synthesis and biological evaluation [J].

Banday, Abid H. ;

Shameem, Shameem A. ;

Gupta, B. D. ;

Kumar, H. M. Sampath .

STEROIDS, 2010, 75 (12) :801-804

[6]

Synthesis of chalcone analogues with increased antileishmanial activity [J].

Boeck, P ;

Falcao, CAB ;

Leal, PC ;

Yunes, RA ;

Cechinel, V ;

Torres-Santos, EC ;

Rossi-Bergmann, B .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (05) :1538-1545

[7]

Anti-HIV-1 protease activity of compounds from Boesenbergia pandurata [J].

Cheenpracha, S ;

Karalai, C ;

Ponglimanont, C ;

Subhadhirasakul, S ;

Tewtrakul, S .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (06) :1710-1714

[8]

DAWANE BS, 2010, INT J PHARM SCI REV, V1, P2

[9]

Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives [J].

Domínguez, JN ;

León, C ;

Rodrigues, J ;

de Domínguez, NG ;

Gut, J ;

Rosenthal, PJ .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (10) :3654-3658

[10]

GURUBASAVARAJA PMS, ACTA PHARM SCI, V50, P197

← 1 2 3 →